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Expression of CD44 spliced variants with both exons v9 and v10 in primary N(-)M(-) breast carcinomas correlates with metastasis

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We analyzed the representation of CD44 isoforms with both exons v9 and v10 among CD44 total amount and also examined correlation between their expression, clinical parameters and survival. We used a semi-quantitative RT-PCR reaction and a panel of 25 normal breast specimens, 10 mammary fibroadenomas, 8 cystic samples and 52 primary breast tumors. CD44 expression level was statistically higher in malignant tumors than in normal breast tissues (p = 0.038) or in fibroadenomas (p = 0.047) and correlated with histological grading, p = 0.047. Ratios CD44 variants with both exons v9 and v10/ total CD44 were similar in normal breast tissues and fibroadenomas but lower in the cystic samples. In primary N(-)M(-) breast tumors, unfavourable outcome and relapse were correlated with low ratios.
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Document Type: Research Article

Affiliations: UNIV HOSP,INST RECH HEMATOL,F-67000 STRASBOURG,FRANCE. UNIV HOSP,DEPT GYNAECOL,F-67000 STRASBOURG,FRANCE. UNIV HOSP,DEPT STOMATOL & PLAST SURG,F-67000 STRASBOURG,FRANCE. UNIV HOSP,DEPT ONCOL,F-67000 STRASBOURG,FRANCE. UNIV HOSP,DEPT ANATOMOPATHOL,F-67000 STRASBOURG,FRANCE. UNIV HOSP,DEPT SURG ONCOL,F-67000 STRASBOURG,FRANCE.

Publication date: January 1, 1997

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  • The International Journal of Oncology provides an international forum for the publication of the latest, cutting-edge research in the broad area of oncology and cancer treatment. The journal accepts original high quality works and reviews on all aspects of oncology research including carcinogenesis, metastasis, epidemiology, chemotherapy and viral oncology. Through fair and efficient peer review, the journal is dedicated to publishing top tier research in the field, offering authors rapid publication as well as high standards of copy-editing and production. The International Journal of Oncology is published on a monthly basis in both print and early online.
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