@article {Battista:1997:1019-6439:65,
title = "Microsatellite instability in early gastric cancer",
journal = "International Journal of Oncology",
parent_itemid = "infobike://sp/ijo",
publishercode ="sp",
year = "1997",
volume = "10",
number = "1",
publication date ="1997-01-01T00:00:00",
pages = "65-70",
itemtype = "ARTICLE",
issn = "1019-6439",
eissn = "1791-2423",
url = "https://www.ingentaconnect.com/content/sp/ijo/1997/00000010/00000001/art00008",
author = "Battista, P and Palmirotta, R and Vitullo, P and Veri, M and Colalongo, C and Rigoli, L and Fedele, F and Caruso, R and Inferrera, C and Romano, F and MarianiCostantini, R and Frati, L and Cama, A",
abstract = "Microsatellite replication errors (RERs), consisting in random tumour-associated allele contractions or expansions, represent a frequent genetic alteration in gastric cancer and appear to be associated with important clinicopathologic parameters. To verify the role of microsatellite
instability in the initial phases of gastric carcinogenesis, we analysed the status of II microsatellites in paired microdissected samples of tumour and unaffected mucosa from 30 cases of early gastric carcinoma. Fifteen tumours (50%) demonstrated RERs: these included 7 cases with RERs at
one locus and 8 cases with RERs at 2 or more loci. Cases with 2 or more RERs were more frequent among intramucosal tumours, compared to tumours with submucosal spread (43% vs. 12%) and among tumours staged T1NOMx, compared to tumours staged T1N1Mx (35% vs. 0%). RER-positive microsatellite
typings were statistically more frequent among tumours with intramucosal extension, lower stage (T1NOMx) and excavated growth pattern (macroscopic type III), compared to tumours with submucosal extension, higher stage (T1N1Mx) and elevated, flat or depressed growth patterns (macroscopic types
IIa-IIb-IIc respectively). The above findings indicate that microsatellite instability occurs early in the progression of sporadic gastric cancer and tends to be associated with good prognostic indicators.",
}