@article {Daidone:1997:1019-6439:41,
title = "Biological predictors of response to radiotherapy in cervical carcinomas",
journal = "International Journal of Oncology",
parent_itemid = "infobike://sp/ijo",
publishercode ="sp",
year = "1997",
volume = "10",
number = "1",
publication date ="1997-01-01T00:00:00",
pages = "41-46",
itemtype = "ARTICLE",
issn = "1019-6439",
eissn = "1791-2423",
url = "https://www.ingentaconnect.com/content/sp/ijo/1997/00000010/00000001/art00004",
author = "Daidone, M and Ricardi, U and Veneroni, S and Faranda, A and Benini, E and Urgesi, A and Sannazzari, G and Silvestrini, R",
abstract = "On 21 patients with T1b-T3b tumours subjected to external radiotherapy and brachytherapy, the expression of P53 and glutathione S-transferase pi [GST-pi], immunohistochemically detected, the S-phase cells fraction (H-3-thymidine labeling index, TLI) and DNA content evaluated by image
analysis were determined on biopsies before and after the first 10 Gy. P53 accumulation was reduced in 60% of P53-overexpressing tumours and not induced in P53-negative tumours, GST-pi was induced in about 40% of pretreatment GST-pi-negative cases, TLI was reduced in 70% of the cases regardless
of pretreatment values, and DNA profiles remained unchanged in two-thirds of the cases. P53 accumulation was a predictor of 3-year relapse-free survival after radiotherapy, followed by GST-pi expression, whereas TLI did not influence prognosis.",
}