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Regional differences of physiological functions and cancer susceptibility in the human large intestine

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Regional differences in function, metabolism and morphology between proximal colon, distal colon and rectum may be important in the pathogenesis and biologic behaviour of tumours originating from these segments. Thus, the effect of primary prevention of colorectal cancer may also differ from one large bowel segment to another. Therefore, this review underscores that one should be careful extrapolating results obtained in a short segment of the large bowel to the entire colorectum. Obviously, future studies concerning the pathogenesis and possibilities for prevention of large bowel cancer should certainly examine results by subsite as a routine procedure.
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Document Type: Research Article

Affiliations: UNIV GRONINGEN HOSP,DEPT INTERNAL MED,DIV GASTROENTEROL,NL-9700 RB GRONINGEN,NETHERLANDS. UNIV GRONINGEN HOSP,DEPT INTERNAL MED,DIV MED ONCOL,NL-9700 RB GRONINGEN,NETHERLANDS.

Publication date: November 1, 1996

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  • The International Journal of Oncology provides an international forum for the publication of the latest, cutting-edge research in the broad area of oncology and cancer treatment. The journal accepts original high quality works and reviews on all aspects of oncology research including carcinogenesis, metastasis, epidemiology, chemotherapy and viral oncology. Through fair and efficient peer review, the journal is dedicated to publishing top tier research in the field, offering authors rapid publication as well as high standards of copy-editing and production. The International Journal of Oncology is published on a monthly basis in both print and early online.
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