THERAPY OF DESMOID TUMORS, FIBROMATOSIS, AND RELATED NEOPLASMS
Forty-seven patients with unresectable desmoid tumors and 32 patients with unresectable fibromatosis were treated with various anti-neoplastic agents including methotrexate, vinblastine, etoposide, actinomycin D, and fluorouracil. A combination of methotrexate with either vinblastine
or etoposide was found to be effective in yielding long-term control to both groups of patients. Fluorouracil and actinomycin D were less effective. Other than a significant but slowly reversible peripheral neuropathy in 6 patients, therapy was well tolerated and no long-term hematologic,
pulmonary, hepatic, or cardiac toxicity was noted in any patient.
Document Type: Research Article
Affiliations: THOMAS JEFFERSON UNIV,SCH MED,DEPT MED,PHILADELPHIA,PA 19107. THOMAS JEFFERSON UNIV,SCH MED,DEPT ORTHOPED SURG,PHILADELPHIA,PA 19107.
Publication date: 01 October 1995
- The International Journal of Oncology provides an international forum for the publication of the latest, cutting-edge research in the broad area of oncology and cancer treatment. The journal accepts original high quality works and reviews on all aspects of oncology research including carcinogenesis, metastasis, epidemiology, chemotherapy and viral oncology. Through fair and efficient peer review, the journal is dedicated to publishing top tier research in the field, offering authors rapid publication as well as high standards of copy-editing and production. The International Journal of Oncology is published on a monthly basis in both print and early online.
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