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THE EXPRESSION OF P53 TUMOR-SUPPRESSOR PROTEIN DURING PROGRESSION OF GASTRIC AND COLORECTAL CARCINOMAS

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The expression of p53 was immunohistochemically determined in sets of biopsies from primary and recurrent colorectal (12) and gastric (17) tumours that had progressed to more advanged stages in the following 6-54 months. At presentation 7 carcinomas overexpressed p53 protein in the cell nucleus and 22 tumours had normal, undetectable levels of p53. In most patients, the p53 phenotype was maintained during the process of tumour progression. In two gastric and two colorectal carcinomas p53 overexpression was subsequently detected in recurrent tumour growth at the primary site and was also associated with the development of metastases. These results suggests that in some cases p53 alterations may contribute to the conversion to malignancy and in others to tumour progression and metastatic capacity.
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Document Type: Research Article

Affiliations: 1: CHRISTIE HOSP NATL HLTH SERV TRUST,PATERSON INST CANC RES,CANC RES CAMPAIGN,DEPT IMMUNOL,MANCHESTER M20 9BX,LANCS,ENGLAND. CHRISTIE HOSP NATL HLTH SERV TRUST,PATERSON INST CANC RES,CANC RES CAMPAIGN,DEPT HISTOL,MANCHESTER M20 9BX,LANCS,ENGLAND. MED POMERANIAN ACAD,DEPT GASTROENTEROL,PL-71344 SZCZECIN,POLAND. UNIV DUNDEE,DEPT BIOCHEM,DUNDEE DR1 4HN,SCOTLAND. 2: CHRISTIE HOSP NATL HLTH SERV TRUST,PATERSON INST CANC RES,CANC RES CAMPAIGN,DEPT IMMUNOL,MANCHESTER M20 9BX,LANCS,ENGLAND. CHRISTIE HOSP NATL HLTH SERV TRUST,PATERSON INST CANC RES,CANC RES CAMPAIGN,DEPT HISTOL,MANCHESTER M20 9BX,LANCS,ENGLAND. MED POMERANIAN ACAD,DEPT GASTROENTEROL,PL-71344 SZCZECIN,POLAND. UNIV DUNDEE,DEPT BIOCHEM,DUNDEE DR1 4HN,SCOTLAND.

Publication date: June 1, 1995

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  • The International Journal of Oncology provides an international forum for the publication of the latest, cutting-edge research in the broad area of oncology and cancer treatment. The journal accepts original high quality works and reviews on all aspects of oncology research including carcinogenesis, metastasis, epidemiology, chemotherapy and viral oncology. Through fair and efficient peer review, the journal is dedicated to publishing top tier research in the field, offering authors rapid publication as well as high standards of copy-editing and production. The International Journal of Oncology is published on a monthly basis in both print and early online.
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