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COMPARATIVE-STUDY OF INTRAMUSCULAR KETOROLAC TROMETHAMINE AND MORPHINE IN PATIENTS EXPERIENCING CANCER PAIN

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Ketorolac tromethamine administered intramuscularly (i.m.) 10 mg 6-hourly was compared with morphine 10 mg i.m. 6-hourly in a randomised, double-blind, cross-over trial for its analgesic efficacy and safety in 51 patients with moderate to severe cancer pain. There was no overall significant difference between the analgesic effect of the two treatments. 57% of ketorolac- and 74% of morphine-treated patients changed their analgesic. Among these, significantly more patients stopped ketorolac than morphine due to pain (p=0.007) whilst more patients discontinued morphine than ketorolac because of adverse effects (p=0.001), predominantly emesis. Only one patient (2%) stopped ketorolac because of intolerance. Ketorolac shows promise as an effective and well tolerated analgesic for cancer pain and merits further study.
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Document Type: Research Article

Affiliations: CHARING CROSS HOSP,DEPT MED ONCOL,LONDON W6 8RF,ENGLAND. ST GEORGE HOSP,SCH MED,DIV ONCOL,LONDON SW17 0RE,ENGLAND. UNIV SASKATCHEWAN,SASKATOON,SK S7N 0X0,CANADA. LADY READING HOSP,MED UNIT A,PESHAWAR,PAKISTAN.

Publication date: June 1, 1995

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  • The International Journal of Oncology provides an international forum for the publication of the latest, cutting-edge research in the broad area of oncology and cancer treatment. The journal accepts original high quality works and reviews on all aspects of oncology research including carcinogenesis, metastasis, epidemiology, chemotherapy and viral oncology. Through fair and efficient peer review, the journal is dedicated to publishing top tier research in the field, offering authors rapid publication as well as high standards of copy-editing and production. The International Journal of Oncology is published on a monthly basis in both print and early online.
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