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RESISTANCE TO TGF-BETA-INDUCED ELIMINATION OF TRANSFORMED-CELLS IS REQUIRED DURING TUMOR PROGRESSION (REVIEW-HYPOTHESIS)

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We present data that extend the present models of transformation and tumor cell progression by one essential step. In vitro, cocultivation of transformed and normal fibroblasts in the presence of TGF-beta leads to the specific elimination of transformed cells due to induction of apoptosis. This mechanism may represent an effective control step early in carcinogenesis. We propose that in vivo, this control mechanism eliminates arising transformed cells unless certain chemicals interfere with this process or the transformed cells have acquired resistance against it. Acquisition of resistance may be an essential requirement for tumor progression.
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Document Type: Research Article

Publication date: June 1, 1995

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  • The International Journal of Oncology provides an international forum for the publication of the latest, cutting-edge research in the broad area of oncology and cancer treatment. The journal accepts original high quality works and reviews on all aspects of oncology research including carcinogenesis, metastasis, epidemiology, chemotherapy and viral oncology. Through fair and efficient peer review, the journal is dedicated to publishing top tier research in the field, offering authors rapid publication as well as high standards of copy-editing and production. The International Journal of Oncology is published on a monthly basis in both print and early online.
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