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EXPRESSION OF ACTIVINS AND ACTIVIN RECEPTOR MESSENGER-RNAS IN LNCAP CELLS, A HUMAN PROSTATIC ADENOCARCINOMA CELL-LINE

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An androgen-responsive human prostatic cell line, LNCaP, was examined for the expression of mRNAs encoding the inhibin/activin subunits and activin receptors as determined by reverse transcription polymerase chain reaction (RT-PCR) and hybridization. Messenger RNA of the beta A- and beta B-subunits of inhibin/activin and activin receptors I, II, and IIB were expressed in these cells. The specificity of the RT-PCR products was confirmed by DNA sequencing. However, the expression of the alpha subunit of inhibin was not observed. In addition, activin proteins were localized immunocytochemically in the cytoplasm of LNCaP cells. The expression of both activins and activin receptors in LNCaP cells suggests that activin may have an autocrine function in these cells. Since activin acts as a modulator of cell proliferation and differentiation in many biological systems and inhibin possesses antagonistic actions to those of activin, it is proposed that the proliferation of LNCaP cells may be associated with an imbalance between the expression of activins and inhibins.
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Document Type: Research Article

Affiliations: UNIV SO CALIF,SCH MED,DEPT CELL & NEUROBIOL,LOS ANGELES,CA 90033.

Publication date: June 1, 1995

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  • The International Journal of Oncology provides an international forum for the publication of the latest, cutting-edge research in the broad area of oncology and cancer treatment. The journal accepts original high quality works and reviews on all aspects of oncology research including carcinogenesis, metastasis, epidemiology, chemotherapy and viral oncology. Through fair and efficient peer review, the journal is dedicated to publishing top tier research in the field, offering authors rapid publication as well as high standards of copy-editing and production. The International Journal of Oncology is published on a monthly basis in both print and early online.
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