THE SELECTIVE-INHIBITION OF VASCULAR-PERMEABILITY FACTOR (VPF) EXPRESSION IN OVARIAN-CARCINOMA CELL-LINES BY GONADOTROPIN-RELEASING-HORMONE (GNRH) AGONIST
GnRH agonists have been found to be clinically useful in several hormone-sensitive conditions, including cancer. However, there is controversy regarding a direct action of these agents on the pathologic tissue of a given disease process, in particular, tumors. In this study, we examined the effects of D-Trp(6) -LHRH, a potent GnRH agonist, on the expression of an increasingly important angiogenesis factor, VPF (vascular permeability factor)/VEGF (vascular endothelial growth factor). Ovarian carcinoma cell lines exposed to D-Trp(6) -LHRH in culture demonstrated a reversible inhibition of VPF mRNA expression and a parallel decrease in the endothelium-specific mitogenic activity of the conditioned media from these treated cultures. This study reports a novel activity of a GnRH agonist and provides a starting point to investigate the in vivo anti-angiogenic properties of GnRH peptide analogs.
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Document Type: Research Article
Affiliations: UNIV MINNESOTA,DEPT PHARMACOL,MINNEAPOLIS,MN 55455.
Publication date: April 1, 1995
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