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PERIOPERATIVE HEPARIN-THERAPY INHIBITS LATE DEATH FROM METASTATIC CANCER

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Low-dose heparin prophylaxis reduces postoperative death from fatal pulmonary embolism and its long-term anti-cancer effect has now been assessed in a retrospective study of 1250 patients, 336 of whom (30%) underwent operation for cancer. There was a striking reduction in three year mortality amongst those patients who received low dose heparin compared to unteated controls (7.6% vs. 12.5%, P=0.005). Death from disseminated malignancy was halved (9.2% vs. 21.4%). The mechanism remains unclear, but may reflect either the antithrombotic actions of heparin or a direct antitumour cell effect.
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Document Type: Research Article

Affiliations: PRINCE WALES HOSP,BRIDGEND,M GLAM,WALES. THROMBOSIS RES INST,LONDON SW3 6LR,ENGLAND.

Publication date: April 1, 1995

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  • The International Journal of Oncology provides an international forum for the publication of the latest, cutting-edge research in the broad area of oncology and cancer treatment. The journal accepts original high quality works and reviews on all aspects of oncology research including carcinogenesis, metastasis, epidemiology, chemotherapy and viral oncology. Through fair and efficient peer review, the journal is dedicated to publishing top tier research in the field, offering authors rapid publication as well as high standards of copy-editing and production. The International Journal of Oncology is published on a monthly basis in both print and early online.
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