ADRENOCORTICAL CARCINOMA - A CLINICAL AND IMMUNOHISTOCHEMICAL STUDY
Twenty-one patients with adrenocortical carcinoma (ACC) were investigated. No correlation was found between size of the primary tumour and the occurrence of metastases, and no correlation was observed between tumour diameter and the functional status of the tumour or survival. Cytokeratins (CK) were expressed in 31% and vimentin (VIM) in 41% of cases. Epithelial membrane antigen (EMA) was detected in one patient with a non-functioning tumour, whereas carcinoembryonic antigen (CEA) was absent in all rumours. The antigens investigated showed no correlation with the morphology or functional status of the tumour. The role of immunohistochemical characterization of this heterogeneous malignancy is discussed.
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Document Type: Research Article
Affiliations: UNIV UPPSALA HOSP,DEPT ONCOL,S-75185 UPPSALA,SWEDEN. UNIV UPPSALA HOSP,DEPT PATHOL,S-75185 UPPSALA,SWEDEN.
Publication date: April 1, 1995
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