Skip to main content
Home / International Journal of Oncology, Volume 3, Number 5

TOWARDS A MORE STANDARDIZED ASSESSMENT OF DIAGNOSTIC TUMOR-MARKERS

Buy Article:

$42.00 + tax (Refund Policy)

Authors: VANDERSCHOUW, YT 1 ; SEGERS, MFG 2 ; SMITS, L 3 ; THOMAS, CMG 2 ; VERBEEK, ALM 2 ; WOBBES, T 3 ; 

Source: International Journal of Oncology, Volume 3, Number 5, 1 November 1993, pp. 979-985(7)

Publisher: Spandidos Publications

The estimation of sensitivity and specificity are mainly used as summary measures of diagnostic power of new diagnostic tests. Unfortunately, the positive assessment outcome is often recanted, frequently because only a preliminary assessment is done in a highly selected population of already diagnosed patients and healthy individuals. Furthermore, diagnostic marker outcomes are dichotomised for the calculation of sensitivity and specificity, with loss of information as a consequence. We plead for the presentation of all relevant diagnostic information, which includes extensive description of the composition of the study group, distributions of test results for different patient groups and the use of the ROC curve and the area under it as the statistical summary measure.

Document Type: Research Article

Affiliations: 1: UNIV HOSP NIJMEGEN,DEPT OBSTET & GYNAECOL,6500 HB NIJMEGEN,NETHERLANDS. UNIV HOSP NIJMEGEN,DEPT GEN SURG,6500 HB NIJMEGEN,NETHERLANDS. UNIV HOSP NIJMEGEN,ENDOCRINOL & REPROD,6500 HB NIJMEGEN,NETHERLANDS. CATHOLIC UNIV NIJMEGEN,DEPT MED INFORMAT & EPIDEMIOL,6500 HB NIJMEGEN,NETHERLANDS. 2: UNIV HOSP NIJMEGEN,DEPT OBSTET & GYNAECOL,6500 HB NIJMEGEN,NETHERLANDS. UNIV HOSP NIJMEGEN,DEPT GEN SURG,6500 HB NIJMEGEN,NETHERLANDS. UNIV HOSP NIJMEGEN,ENDOCRINOL & REPROD,6500 HB NIJMEGEN,NETHERLANDS. CATHOLIC UNIV NIJMEGEN,DEPT MED INFORMAT & EPIDEMIOL,6500 HB NIJMEGEN,NETHERLANDS. 3: UNIV HOSP NIJMEGEN,DEPT OBSTET & GYNAECOL,6500 HB NIJMEGEN,NETHERLANDS. UNIV HOSP NIJMEGEN,DEPT GEN SURG,6500 HB NIJMEGEN,NETHERLANDS. UNIV HOSP NIJMEGEN,ENDOCRINOL & REPROD,6500 HB NIJMEGEN,NETHERLANDS. CATHOLIC UNIV NIJMEGEN,DEPT MED INFORMAT & EPIDEMIOL,6500 HB NIJMEGEN,NETHERLANDS.

Publication date: 01 November 1993

More about this publication?
  • The International Journal of Oncology provides an international forum for the publication of the latest, cutting-edge research in the broad area of oncology and cancer treatment. The journal accepts original high quality works and reviews on all aspects of oncology research including carcinogenesis, metastasis, epidemiology, chemotherapy and viral oncology. Through fair and efficient peer review, the journal is dedicated to publishing top tier research in the field, offering authors rapid publication as well as high standards of copy-editing and production. The International Journal of Oncology is published on a monthly basis in both print and early online.
  • Editorial Board
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Information for Advertisers
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites

Share Content

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content