LACK OF PROGNOSTIC VALUE OF IMMUNOHISTOCHEMICAL DETERMINATION OF EPIDERMAL GROWTH-FACTOR RECEPTORS IN HUMAN PROSTATE-CANCER
We have investigated whether the expression of Epidermal Growth Factor Receptors (EGF-Rc) evaluated by immunohistochemical technique, may influence the prognosis of patients with prostate cancer. EGF-Rc were positive in 20/76 (26.3%) of tumors. There was no correlation between EGF-Rc
and other prognostic factors such as tumor size, Gleason score, metastases at diagnosis, DNA content and S-Phase fraction (SPF). In patients with locally advanced tumors EGF-Rc expression was significantly correlated with the presence of metastases at diagnosis (p=0.038). Both disease-free
survival (DFS) and overall survival (OS) did not differ between patients with receptor-positive and receptor-negative tumors. It is concluded that the immunohistochemical localization of EGF-Rc is of limited prognostic value in prostate cancer.
Document Type: Research Article
Affiliations: UNIV G DANNUNZIO,CATTEDRA ONCOL MED,VIA VESTINI 66,I-66100 CHIETI,ITALY. UNIV G DANNUNZIO,IST ANAT PATOL,I-66100 CHIETI,ITALY. UNIV G DANNUNZIO,UROL CLIN,I-66100 CHIETI,ITALY.
Publication date: 01 November 1993
- The International Journal of Oncology provides an international forum for the publication of the latest, cutting-edge research in the broad area of oncology and cancer treatment. The journal accepts original high quality works and reviews on all aspects of oncology research including carcinogenesis, metastasis, epidemiology, chemotherapy and viral oncology. Through fair and efficient peer review, the journal is dedicated to publishing top tier research in the field, offering authors rapid publication as well as high standards of copy-editing and production. The International Journal of Oncology is published on a monthly basis in both print and early online.
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