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EXPRESSION OF MULTIDRUG RESISTANCE (P-GLYCOPROTEIN) MDR1 AND MDR2 GENES IN HUMAN HEPATOCELLULAR CARCINOMAS AND LIVER METASTASES OF COLONIC TUMORS

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Overexpression of P-glycoproteins (P-gp), encoded by multidrug resistance (MDR) genes is responsible for multidrug resistance in animal cells. We analyzed the expression of MDR genes in human hepatocellular carcinomas (HCC) and liver metastases of colon tumors by an RNase protection assay. Our results indicated that both genes were not consistently overexpressed in these tumors, whereas MDR2 is often underexpressed in the metastatic tumors. Invasion of colon tumors to livers decreased MDR1 expression. These data suggest differential regulation mechanisms for the expression of MDR1 and MDR2 genes in these tumors, and a complex drug-resistance mechanism for liver cancers.
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Document Type: Research Article

Affiliations: UNIV TEXAS,MD ANDERSON CANC CTR,DEPT MOLEC PATHOL,1515 HOLCOMBE BLVD,HOUSTON,TX 77030. HUNTINGTON HOSP,PASADENA,CA. NATL TAIWAN UNIV HOSP,DEPT PATHOL,TAIPEI 100,TAIWAN.

Publication date: January 1, 1993

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  • The International Journal of Oncology provides an international forum for the publication of the latest, cutting-edge research in the broad area of oncology and cancer treatment. The journal accepts original high quality works and reviews on all aspects of oncology research including carcinogenesis, metastasis, epidemiology, chemotherapy and viral oncology. Through fair and efficient peer review, the journal is dedicated to publishing top tier research in the field, offering authors rapid publication as well as high standards of copy-editing and production. The International Journal of Oncology is published on a monthly basis in both print and early online.
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