INVIVO PHARMACOKINETICS OF THE ANTITUMOR AGENT 4,6-BENZYLIDENE-D-GLUCOSE (BG) AND A DEUTERATED ANALOG 4,6-BENZYLIDENE-D1-D-GLUCOSE (P-1013) IN MICE, RATS AND DOGS
In vivo pharmacokinetics of the antitumour agent 4,6-benzylidene-D-glucose (BG) and a deuterated analog 4,6-benzylidene-d1-D-glucose (P-1013) were investigated in athymic mice, Beagle dogs and Wistar rats following i.v. administration of the compounds. Reverse-phase high performance liquid chromatography (HPLC) was used to quantitate drug and metabolite content in plasma samples. No difference in the half-life (t1/2) for BG and P-1013 was observed in any of the three species, the half-lives were on the order of 10 min. Metabolism of BG and P-1013 leads to formation of undeuterated and deuterated 1,3-benzylidene-D-glucitol, respectively, as the only detectable metabolites. The half-lives of these metabolites were also measured and were found to differ between rats given undeuterated and deuterated drug. In mice and dogs the t1/2 was the same for deuterated and undeuterated 1,3-benzylidene-D-glucitol.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
Document Type: Research Article
Affiliations: PRONOVA AS,DEPT PHARMACOL,N-0371 OSLO,NORWAY.
Publication date: January 1, 1993
More about this publication?
- The International Journal of Oncology provides an international forum for the publication of the latest, cutting-edge research in the broad area of oncology and cancer treatment. The journal accepts original high quality works and reviews on all aspects of oncology research including carcinogenesis, metastasis, epidemiology, chemotherapy and viral oncology. Through fair and efficient peer review, the journal is dedicated to publishing top tier research in the field, offering authors rapid publication as well as high standards of copy-editing and production. The International Journal of Oncology is published on a monthly basis in both print and early online.
- Editorial Board
- Information for Authors
- Submit a Paper
- Subscribe to this Title
- Information for Advertisers
- Terms & Conditions
- Ingenta Connect is not responsible for the content or availability of external websites