FATAL ATTRACTION - THE FOS-JUN AFFAIR WITH NUCLEAR RECEPTORS
The modulation of cell physiology forms the basis of cellular growth and differentiation. Aberrant steps in this process are responsible for deregulated proliferation and constitute the molecular causes of tumorigenic development. Signal transduction events regulate gene expression
by modulating the activity of transcription factors. Two principal pathways are used by the cell to convey signals to the nucleus. In one, cell surface receptors bind growth factors or peptide hormones and thereby activate intracellular signalling systems. In this case, transcription factors
are targets for modification by transduction pathways. The other pathway involves nuclear receptors which bind to steroid and thyroid hormones, vitamin D and retinoic acid. In this case the nuclear receptors themselves are transcriptional regulators.
Document Type: Research Article
Publication date: 01 June 1992
- The International Journal of Oncology provides an international forum for the publication of the latest, cutting-edge research in the broad area of oncology and cancer treatment. The journal accepts original high quality works and reviews on all aspects of oncology research including carcinogenesis, metastasis, epidemiology, chemotherapy and viral oncology. Through fair and efficient peer review, the journal is dedicated to publishing top tier research in the field, offering authors rapid publication as well as high standards of copy-editing and production. The International Journal of Oncology is published on a monthly basis in both print and early online.
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