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BMP6 protects retinal pigment epithelial cells from oxidative stressinduced injury by inhibiting the MAPK signaling pathways

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Worldwide, neovascular agerelated macular degeneration (nAMD) is one of the most common causes of blindness in the elderly. In particular, degeneration of retinal pigment epithelial (RPE) cells represents the main pathological process in the development of nAMD, and oxidative stress serves a major role. The present study aimed to investigate the association between bone morphogenetic protein 6 (BMP6) and nAMD. BMP6 concentration was significantly reduced in patients with wet nAMD compared with in the control group. Furthermore, the present study investigated the protective effects of BMP6 on RPE cells following oxidative stressinduced injury. Cell Counting Kit8 assay and terminal deoxynucleotidyl transferase dUTP nickend labeling staining demonstrated that BMP6 increased RPE cell viability, which was decreased following treatment with hydrogen peroxide (H2O2), and reduced H2O2induced apoptosis. In addition, western blotting revealed that BMP6 reversed the decrease in procaspase3 levels and the dysregulation of the Bcell lymphoma 2 (Bcl2)/Bcl2associated X protein (Bax) balance caused by H2O2. In addition, alterations in cJun Nterminal protein kinase (JNK) and p38 mitogenactivated protein kinase (MAPK) expression were examined, and pretreatment with BMP6 was demonstrated to reduce H2O2induced activation of JNK and p38 MAPK. Conversely, the effects of BMP6 were attenuated by its inhibitor noggin. In conclusion, the present study demonstrated that BMP6 may protect RPE cells from oxidative stress injury to a certain extent, which may be associated with alterations in the MAPK signaling pathway. However, the specific mechanism of action underlying this effect requires further investigation. Overall, the present study laid a foundation for exploring novel nAMD treatment methods.
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Document Type: Research Article

Affiliations: 1: Department of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China 2: Department of Ophthalmology, The First Hospital of Xi'an, Xi'an, Shaanxi 710002, P.R. China 3: Institute of Neurobiology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, P.R. China

Publication date: January 1, 2018

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  • The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.

    The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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