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Role of TGFβ1 expressed in bone marrowderived mesenchymal stem cells in promoting bone formation in a rabbit femoral defect model

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Bone defects represent a major clinical and socioeconomic problem without suitable treatment options. Previous studies have shown that transforming growth factor β1 (TGFβ1) is important in the development of various diseases. The present study aimed to investigate the therapeutic potential of rabbit bone marrowderived mesenchymal stem cells (BMSCs) expressing TGFβ1 in the treatment of rabbit femoral defects. First, rabbit BMSCs were identified and cultured. TGFβ1 was then stably overexpressed in the rabbit BMSCs by lentivirus transfection, which was expressed at a high level in the femoral defects treated with TGFβ1overexpressing BMSCs, compared with PBStreated controls. In addition, the TGFβ1overexpressing BMSCs promoted new bone formation in the rabbit femoral defect model, and increased the expression of bonerelated markers at week 2 and week 6. Therefore, the study demonstrated that BMSCs overexpressing TGFβ1 may provide a novel therapeutic option for femoral defects.
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Document Type: Research Article

Affiliations: 1: Department of Orthopedics, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, Guangdong 528200, P.R. China 2: Department of Orthopedics, Linyi People's Hospital, Linyi, Shandong 276000, P.R. China 3: Department of Substance Dependence, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, Guangdong 510370, P.R. China 4: Physical Examination Center, The Second Traditional Chinese Medicine Hospital of Guangdong Provence, Guangzhou, Guangdong 510095, P.R. China 5: Department of Microsurgery II, Wendeng Hospital of Traditional Chinese of Orthopedics and Traumatology of Shandong, Wendeng, Shandong 264400, P.R. China 6: Department of Orthopedics, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510405, P.R. China

Publication date: January 1, 2018

More about this publication?
  • The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.

    The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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