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Home / International Journal of Molecular Medicine, Volume 39, Number 6

Human osteopontin: Potential clinical applications in cancer (Review)

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Authors: Hao 1 ; Cui 2 ; Owen 2 ; Li 3 ; Cheng 1 ; Jiang 1 ; 

Source: International Journal of Molecular Medicine, Volume 39, Number 6, 2017, pp. 1327-1337(11)

Publisher: Spandidos Publications

DOI: https://doi.org/10.3892/ijmm.2017.2964

Human osteopontin (OPN) is a glycosylated phosphoprotein which is expressed in a variety of tissues in the body. In recent years, accumulating evidence has indicated that the aberrant expression of OPN is closely associated with tumourigensis, progression and most prominently with metastasis in several tumour types. In this review, we present the current knowledge on the expression profiles of OPN and its main splice variants in human cancers, as well as the potential implications in patient outcome. We also discuss its putative clinical application as a cancer biomarker and as a therapeutic target.

Document Type: Research Article

Affiliations: 1: Department of Biochemistry and Molecular Biology, Capital Medical University, Beijing 100069, P.R. China 2: Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK 3: Department of Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China

Publication date: 01 January 2017

More about this publication?
  • The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.

    The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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