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Tachycardia-bradycardia syndrome: Electrophysiological mechanisms and future therapeutic approaches (Review)

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Sick sinus syndrome (SSS) encompasses a group of disorders whereby the heart is unable to perform its pacemaker function, due to genetic and acquired causes. Tachycardiabradycardia syndrome (TBS) is a complication of SSS characterized by alternating tachycardia and bradycardia. Techniques such as genetic screening and molecular diagnostics together with the use of pre-clinical models have elucidated the electrophysiological mechanisms of this condition. Dysfunction of ion channels responsible for initiation or conduction of cardiac action potentials may underlie both bradycardia and tachycardia; bradycardia can also increase the risk of tachycardia, and vice versa. The mainstay treatment option for SSS is pacemaker implantation, an effective approach, but has disadvantages such as infection, limited battery life, dislodgement of leads and catheters to be permanently implanted in situ. Alternatives to electronic pacemakers are genebased bioartificial sinoatrial node and cellbased bioartificial pacemakers, which are promising techniques whose long-term safety and efficacy need to be established. The aim of this article is to review the different ion channels involved in TBS, examine the threeway relationship between ion channel dysfunction, tachycardia and bradycardia in TBS and to consider its current and future therapies.
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Document Type: Research Article

Affiliations: 1: Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, SAR 2: Tianjin Key Laboratory of IonicMolecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China 3: Faculty of Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK 4: Intensive Care Department, Royal Brompton and Harefield NHS Foundation Trust, London SW3 6NP, UK 5: Stem Cell and Regenerative Medicine Consortium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, SAR, P.R. China 6: School of Biological Sciences, University of Cambridge, Cambridge CB2 1AG, UK 7: Li DakSum Research CentreHKUKarolinska Institutet Collaboration on Regenerative Medicine, University of Hong Kong, Hong Kong, SAR, P.R. China

Publication date: January 1, 2017

More about this publication?
  • The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.

    The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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