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Autografting of bone marrow mesenchymal stem cells alleviates streptozotocininduced diabetes in miniature pigs: Realtime tracing with MRI in vivo

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Cellular replacement therapy for diabetes mellitus (DM) has received much attention. In this study, we investigated the effect of transplantation of autologous bone marrowderived mesenchymal stem cells (ABMSCs) in streptozotocin (STZ)induced diabetic miniature pigs. Miniature pig BMSCs were cultured, labeled with superparamagnetic iron oxide (SPIO) and transplanted into the pancreas of diabetic miniature pigs through targeted intervention. Blood glucose levels, intravenous and oral glucose tolerance test (OGTT), serum insulin, Cpeptide and islets histology were analyzed. These transplanted cells were then identified by magnetic resonance imaging (MRI). The results showed that transplantation of ABMSCs reversed STZinduced diabetes in miniature pigs. Blood glucose levels, intravenous, OGTT, serum insulin and Cpeptide were significantly recovered in the diabetic minipigs with the autologous BMSC (DMAB) transplantation group. In addition, the number of islets was significantly increased in this group compared to the diabetic minipig control (DMC) group with conventional therapy. These data suggested the implantation of autologous BMSCs for type 1 diabetes treatment can partially restore the function of islet β cells and maintain blood glucose homeostasis. Transplanted autologous BMSCs may improve islet repairing by differentiating for new islets and change pancreatic microcirculation and be identified in a realtime manner using MRI in vivo.
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Document Type: Research Article

Affiliations: 1: Department of Endocrinology, The Third Affiliated Hospital of Sun Yatsen University, Guangzhou, Guangdong 510630, P.R. China 2: Department of Nephrology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China 3: Department of Vascular Surgery and Radiology, The First Affiliated Hospital of Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China 4: Department of Geriatrics, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China

Publication date: June 1, 2014

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  • The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.

    The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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