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In vitro assessment of the dual-targeting behavior of a peptide-based magnetic resonance imaging contrast agent

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In this study, a peptide-based dual-targeting magnetic resonance imaging (MRI) contrast agent (S8) was designed and synthesized. Arg-Gly-Asp (RGD) and Asn-Gly-Arg (NGR) were combined in the targeting vector so as to allow binding, on the surface of tumor cells, to integrin αvβ3 and aminopeptidase N (CD13), respectively. The longitudinal relaxivity (r1) value of S8 was 8.297 mM-1sec-1 at a magnetic field of 11.7 T, which is approximately double the r1 value (4.25 mM-1sec-1) of Magnevist, a commercially available contrast agent. MDA-MB-231 human breast cancer cells (which overexpress αvβ3) and human prostate cancer cells PC-3 (which overexpress CD13) were used to investigate the tumortargeting behavior of S8. The results from the present study indicate that the designed contrast agent, S8, targets both MDA-MB231 and PC-3 cells.
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Document Type: Research Article

Affiliations: 1: School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430007, P.R. China 2: Division of Nanobionics, Suzhou Institute of Nanotech and Nanobionics, Chinese Academy of Sciences, Suzhou, Jiangsu 215123, P.R. China 3: Division of Nanobiomedicine, Suzhou Institute of Nanotech and Nanobionics, Chinese Academy of Sciences, Suzhou, Jiangsu 215123, P.R. China

Publication date: January 1, 2014

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  • The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.

    The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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