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Protective effects of nimodipine on cerebrovascular function in chronic alcoholic encephalopathy

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In the present study, we used chronic gavage administration of alcohol with gradual increases in alcohol concentration and volume to generate a rat model of chronic alcohol intoxication. We measured the changes in biological, behavioral, pathological and vascular injury-related molecular biological markers, and explored the effects of nimodipine intervention on alcohol intoxication. We found that chronic alcohol consumption induced a variety of behavioral abnormalities, accompanied by severe pathological changes in cerebral arterioles, prefrontal cortex and cerebellar tissue, as well as an upregulation of vascular endothelial growth factor (VEGF), leptin receptor (ob-R) and endothelin-1 (ET-1). Treatment with mimodipine for 15 days significantly improved behavioral abnormalities, alleviated the pathological changes in blood vessels and brain tissues, increased VEGF expression, decreased ob-R expression, reduced plasma ET-1 leakage and protected vascular and neuronal functions.
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Document Type: Research Article

Affiliations: 1: Department of Neurology, Jinan Fourth People's Hospital, Jinan, Shandong, P.R. China 2: Department of Neurology, Shandong University Qilu Hospital, Jinan, Shandong, P.R. China 3: Department of Gynecotokology, Jinan Central Hospital, Jinan, Shandong, P.R. China 4: Department of Emergency, Jinan Fourth People's Hospital, Jinan, Shandong, P.R. China 5: Clinical Laboratory, Jinan Fourth People's Hospital, Jinan, Shandong, P.R. China

Publication date: January 1, 2014

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  • The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.

    The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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