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Identification of ankylosing spondylitis-associated genes by expression profiling

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Ankylosing spondylitis (AS) is a chronic inflammation attacking the sacroiliac joints and the spine. Certain genes have been associated with the occurrence of AS. Gene chip data were utilized to recognize genes associated with AS for the association of the clinical diagnosis and the biomedical study. Microarray expression data of AS were acquired from the public microarray database GEO (gene expression omnibus), and AS-related genes were obtained by differential gene expression profiling. The transcriptional and translational levels of these genes were further examined. The transcriptional and translational levels of three genes were shown to be upregulated in a mouse model of AS by real-time PCR and Elisa assay, respectively. Differential expression of AS-related genes was identified by analysis of gene chip data, contributing to the advancement of the understanding of the pathogenesis of AS.
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Document Type: Research Article

Affiliations: Department of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai, P.R. China

Publication date: January 1, 2012

More about this publication?
  • The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.

    The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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