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Home / International Journal of Molecular Medicine, Volume 29, Number 5

Anti-aging effects of high molecular weight proteoglycan from salmon nasal cartilage in hairless mice

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Authors: Goto 1 ; Yamazaki 2 ; Kato 3 ; Yamamoto 4 ; Katagata 2 ; 

Source: International Journal of Molecular Medicine, Volume 29, Number 5, 2012, pp. 761-768(8)

Publisher: Spandidos Publications

DOI: https://doi.org/10.3892/ijmm.2012.918

Proteoglycans comprise a family of complex macromolecules consisting of a core protein with covalently attached glycosaminoglycan (GAG) chains. The skin anti-aging effects of oral administration of proteoglycan fractions with different molecular weights from salmon nasal cartilage were investigated in a hairless mouse model of skin aging; aging was caused by repeated ultraviolet B (UVB) irradiation. Three proteoglycan fractions of different molecular weights were prepared from salmon nasal cartilage water extract by ion-exchange column chromatography and gel filtration column chromatography. Physiological and histological analysis of the skin indicated that oral administration of high molecular weight proteoglycan inhibited UVB-induced skin aging, defined as increased erythema, increased transepidermal water loss (TEWL), decreased hydration, and epidermal and dermal hypertrophies. The serum and dorsal skin inflammatory cytokine levels indicated that high molecular weight proteoglycan acts on gut immunity and improves skin by inhibiting surplus inflammatory cytokines produced by UVB irradiation. These results suggest that high molecular weight proteoglycan from salmon nasal cartilage is effective in preventing skin aging.

Document Type: Research Article

Affiliations: 1: Science of Bioresources, The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Japan 2: Department of Biochemistry and Biotechnology, Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki, Japan 3: Laboratory of Food Science, Faculty of Education, Hirosaki University, Hirosaki, Japan 4: R__AMB__D Department, Sunstar Inc., Takatsuki, Japan

Publication date: 01 January 2012

More about this publication?
  • The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.

    The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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