Female patients with atrial fibrillation have increased oxidized and glycated lipoprotein properties and lower apolipoprotein A-I expression in HDL
It is well-known that oxidative stress and inflammatory processes are linked to the incidence of atrial fibrillation (AF). In order to provide prognostic biomarkers for AF based on lipoprotein levels, we compared the lipid and protein parameters of oxidation and inflammation in individual
lipoproteins from middle-aged females with AF. We analyzed plasma and lipoproteins (VLDL, LDL, HDL2, HDL3) from 11 female patients (mean age, 56±15 years) with paroxysmal lone AF and from a reference group of 10 female patients of similar age (mean age, 54±15 years). The AF group
had normal levels of serum lipids and an inflammatory profile, except for a 7.5- and 6-fold elevation in hsCRP and tropoinin I levels, respectively. No significant differences existed in serum lipids, glucose, uric acid, creatinine and blood urea nitrogen levels between the AF and control
groups. The lipoprotein particles from the AF group were more oxidized and glycated with higher triacylglycerol content compared to the control group and the particle size was smaller. The lipoprotein particles from the AF group promoted more foam cell formation via accelerated phagocytosis
by macrophages compared to the control group. HDL2 and HDL3 from the AF group showed decreased antioxidant ability and an approximately 30% lower expression of apoA-I compared to the control group. All of these modified properties of lipoproteins, including oxidation and glycation, might be
linked to the lower antioxidant ability and elevated inflammatory parameters in women with AF.
Document Type: Research Article
Affiliations: 1: School of Biotechnology, Aging-Associated Vascular Disease Research Center, Yeungnam University, Gyeongsan 712-749, Republic of Korea 2: School of Biotechnology, Yeungnam University, Gyeongsan 712-749, Republic of Korea
Publication date: 01 June 2011
- The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.
The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases. - Editorial Board
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