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Corilagin inhibits the double strand break-triggered NF-κB pathway in irradiated microglial cells

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Microglia, the resident immune cells of the central nervous system (CNS), are activated by various stimuli. Resting microglia are the basis of normal neurogenesis, while activated microglia may inhibit neurogenesis through the production of pro-inflammatory mediators and cytokines. Recent research suggests that microglia are activated by irradiation. This may play a role in radiation-induced brain injury (RIBI). DNA double-strand breaks (DSBs), the most deleterious form of DNA damage after ionizing radiation, may rapidly trigger the activation of the NF-κB pathway via p53-induced protein leading to the release of pro-inflammatory mediators and cytokines. Thus, a negative regulator of the NF-κB pathway that inhibits radiation-induced microglia activation could be used to treat RIBI. Corilagin, a member of the tannin family, inhibits NF-κB pathway activation. In the present study, we examined the inhibitory effects of corilagin on radiation-induced microglia activation using a variety of techniques. Our data suggest that corilagin inhibits radiation-induced microglia activation via suppression of the NF-κB pathway and the compound is a potential treatment for RIBI.
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Document Type: Research Article

Affiliations: Cancer Center, Huazhong University of Science and Technology, Wuhan, P.R. China

Publication date: April 1, 2010

More about this publication?
  • The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.

    The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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