@article {Zhang:2008:1107-3756:677,
title = "Induction of tumor cell apoptosis by taurine Schiff base copper complex is associated with the inhibition of proteasomal activity",
journal = "International Journal of Molecular Medicine",
parent_itemid = "infobike://sp/ijmm",
publishercode ="sp",
year = "2008",
volume = "22",
number = "5",
publication date ="2008-11-01T00:00:00",
pages = "677-682",
itemtype = "ARTICLE",
issn = "1107-3756",
eissn = "1791-244X",
url = "https://www.ingentaconnect.com/content/sp/ijmm/2008/00000022/00000005/art00015",
doi = "doi:10.3892/ijmm_00000072",
author = "Zhang, Xia and Bi, Caifeng and Fan, Yuhua and Cui, Qiuzhi and Chen, Di and Xiao, Yan and Dou, Q. Ping",
abstract = "Schiff bases have been intensively investigated due to their antibacterial and antitumor properties. Copper is a cofactor essential for the tumor angiogenesis processes, whereas other transition metals are not. Consistently, high serum or tissue levels of copper were found in many types
of human cancer including breast, prostate, colon, lung, and brain, supporting the idea that copper could be used as a novel selective target for cancer therapies. In the current study we hypothesize that a synthetic taurine Schiff base copper complex (Compound 1) could suppress tumor cell
growth via the direct inhibition of proteasomal activity. Compound 1 potently inhibits the activity of purified 20S and 26S proteasome in human breast cancer MDA-MB-231 and leukemia Jurkat T cells. Inhibition of tumor cellular proteasomal activity by Compound 1 results in the accumulation
of ubiquitinated protein and the proteasome target proteins p27 and Bax, followed by the induction of apoptosis. Our results strongly suggest that taurine Schiff base copper complexes, as potent proteasome inhibitors, have great potential to be developed into novel anticancer drugs.",
}