@article {Kato:2007:1107-3756:933,
title = "Genetic factors for lone atrial fibrillation",
journal = "International Journal of Molecular Medicine",
parent_itemid = "infobike://sp/ijmm",
publishercode ="sp",
year = "2007",
volume = "19",
number = "6",
publication date ="2007-01-01T00:00:00",
pages = "933-939",
itemtype = "ARTICLE",
issn = "1107-3756",
eissn = "1791-244X",
url = "https://www.ingentaconnect.com/content/sp/ijmm/2007/00000019/00000006/art00010",
author = "Kato and Oguri and Hibino and Yajima and Matsuo and Segawa and Watanabe and Yoshida and Satoh and Nozawa and Yokoi and Yamada",
abstract = "Atrial fibrillation (AF) may result from an electric conduction disturbance, increased hemodynamic stress, ischemia, inflammation, or remodeling in atria. Although genetic epidemiological studies have identified several genetic variants as risk factors for AF, the genetic determinants
of this condition remain largely unknown. The purpose of the present study was to identify gene polymorphisms that confer susceptibility to lone AF. The study population comprised 1069 unrelated Japanese individuals, including 196 subjects with chronic lone AF and 873 controls. The genotypes
for 40 polymorphisms of 32 candidate genes were determined by a method that combines the polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. Multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the
prevalence of smoking, hypertension, diabetes mellitus, and hyperchole-sterolemia as well as a stepwise forward selection procedure revealed that the -1306CT polymorphism of the matrix metalloproteinase 2 gene (MMP2) and the -592AC polymorphism of the interleukin 10 gene (IL10)
were significantly (false discovery rate of <0.05) associated with the prevalence of AF. The T allele of the MMP2 polymorphism and the C allele of the IL10 polymorphism were a risk factor for and protective factor against AF, respectively. Determination of the genotypes for these polymorphisms
may thus prove informative for assessment of the genetic component of AF.",
}