Induction of apoptosis by ar-turmerone on various cell lines
This study investigated the cytotoxic effect of ar-turmerone isolated from turmeric (Curcuma longa L) on the K562, L1210, U937 and RBL-2H3 cell lines by the MTT assay. Ar-turmerone exhibited potent cytotoxicity on these cancer cell lines. The IC50 values of ar-turmerone on these cell lines were 20-50 µg/ml. They showed an increased inhibition ratio on cell viability according to the drug concentration ≤80 µg/ml in the cell lines tested. The DNA fragmentation that is a characteristic of apoptosis due to ar-turmerone occurred in a concentration- and time-dependent manner in the K562, L1210, U937 and RBL-2H3 cancer cell lines. These results suggest that ar-turmerone can induce the apoptotic activity in the K562, L1210, U937 and RBL-2H3 cells.
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Document Type: Research Article
Affiliations: School of Life Science, Shandong University, Jinan 250100, China
Publication date: August 1, 2004
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- The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.
The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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