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Delayed interconversion of D-glucose anomers in D2O

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The anomeric specificity of D-glucose metabolism and functional effects is currently assessed either over about 5 min at 37°C or longer periods at much lower temperatures. In the present study, the half-life for the interconversion of D-glucose anomers at 30°C was found to be increased (P<0.005) from 17.2±0.9 min in a mixture of H2O/D2O (9/1, v/v) to 58.6±1.9 min in pure D2O. It is proposed that advantage can be taken from this delayed interconversion in D2O in experiments dealing with the anomeric specificity of D-glucose metabolic fate and functional effects. Thus, even over 60-min incubation at 30°C, the integrated mean abundance of α- and β-D-glucose would remain close to 82 and 89%, respectively, of the corresponding initial value (100%).
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Document Type: Research Article

Affiliations: Laboratory of Experimental Hormonology, Brussels Free University, B-1070 Brussels, Belgium., Email: [email protected]

Publication date: June 1, 2004

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  • The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.

    The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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