Helicobacter pylori cytotoxin: A novel ligand for receptor-like protein tyrosine phosphatase β (Review)
The impacts of toxins are generally observed as acute intoxications, whereas the environmental health effects of chronic exposure to mostly low levels of toxins are only poorly documented and are an emerging issue. Furthermore, toxins are potentially useful as tools to study the physiological
role of particular channels or to determine structural features of channels that are important for their function. Recent studies suggest that vacuolating cytotoxin (VacA) is a novel ligand for receptor protein tyrosine phosphatase (RPTP) β. VacA is a virulence factor of Helicobacter
pylori that is involved in gastric ulceration and cancer in experimental animals and humans. VacA may represent the chronic exposure of A-B family of bacterial endotoxins and be a useful probe for RPTPβ functions in the gastrointestinal system.
Document Type: Research Article
Affiliations: Inui Clinic, Osaka, Japan
Publication date: 01 December 2003
- The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.
The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases. - Editorial Board
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