A novel single-nucleotide substitution, Leu 467 Pro, in the interferon-γ receptor 1 gene associated with allergic diseases
We identified a novel heterozygous single-nucleotide substitution 1400 T↷C (Leu 467 Pro) in the seventh exon of the interferon-γ receptor 1 (IFNGR1) gene. This substitution was detected in 6 of the 89 allergic patients but not in the 72 non-allergic subjects. There was
a difference in the L467P frequency between the allergic patients and the non-allergic subjects (Fisher's exact test: p=0.033). The 6 patients with L467P have allergic diseases such as bronchial asthma and/or allergic rhinitis. Furthermore, a familial analysis for L467P revealed a linkage
between allergic diseases and L467P. Serum IgE levels of the patients with L467P were higher than those of the non-allergic subjects (p=0.001). Our previous studies have been shown that interferon-γ (IFN-γ) production by PBMCs in the allergic patients was lower than that in the
non-allergic subjects. In this study, although IFN-γ production in the allergic patients with L467P was equivalent to that in the non-allergic subjects, their serum IgE levels were high and they had allergic diseases. Our results suggest that some allergic patients have IFNGR dysfunction,
and that L467P in the IFNGR1 gene is one of candidate susceptibility genes for allergic diseases.
Document Type: Research Article
Affiliations: Department of Pediatrics, Gifu University School of Medicine, Gifu 500-8705, Japan., Email: [email protected]
Publication date: 01 August 2003
- The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.
The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases. - Editorial Board
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