Altered DNA repair capacity in young patients suffering from multiple cancers
Young patients less than 45 years old suffering from multiple cancers but lacking typical risk factors were evaluated for genetic instability. Peripheral blood lymphocytes were isolated and DNA repair capacity was investigated using alkaline microgel electrophoresis and compared to matched normal controls. While normal lymphocytes had an average DNA repair capacity of 95.3%, those isolated from cancer patients had 81.3% (p<0.01). While 10 patients with multiple cancer showed compatible repair capacity to healthy donors, 9 patients had a distinct reduced DNA repair capacity much lower than triple standard deviation. It must be assumed, that this subgroup of the cancer patients has a genetic background of reduced DNA repair capacity or processing and that development of multiple cancer may be due to genetic instability. These results will impact not only the developing of new diagnostic and screening strategies, but will also guide further research targeting the underlying mechanisms of DNA repair relating to cancer.
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Document Type: Research Article
Affiliations: Department of Otorhinolaryngology, Head and Neck Surgery, University of Erlangen/Nürnberg, 91054 Erlangen, Germany., Email: [email protected]
Publication date: May 1, 2003
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- The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.
The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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