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Influence of allergen-specific immunotherapy on IL-4-dependent IL-12 production by monocytes

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Allergen-specific immunotherapy (AIT) is an effective method of allergy treatment. Reduction of allergy symptoms followed by AIT presumably depends on modification of cytokine production, especially of IFN-γ and/or IL-4. Previously, we found that lower IL-12 production by allergic monocytes than in healthy control, could depend on higher IL-4 receptor α-chain (CD124) expression. Since IFN-γ production is stimulated by IL-12, which in turn is down-regulated by IL-4, the aim of study was to analyze the influence of AIT on the network of these cytokines. Moreover, we estimated the possible role of CD124 in that process. Patients (n=16) with grass pollen allergy were subjected to AIT with Allergovit for 5 to 6 weeks. The clinical examination and blood analyses were performed before and after AIT. Clinical improvement in course of AIT was rather weak, however, we found significant increase of mean IFN-γ production by PBMC. Although the increase of mean IL-12 production by monocytes following AIT was non-significant, we observed statistically significant decrease of monocyte sensitivity to IL-4 suppressed IL-12 production. Flow cytometry analysis revealed significant decrease of CD124 expression on monocytes after AIT. Despite unchanged mean IL-4 level the decrease of CD124 expression after AIT could explain the decreased monocyte sensitivity to IL-4 and its role in further IL-12 and IFN-γ tuning.
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Document Type: Research Article

Affiliations: Clinic of Pulmonology, Allergic Diseases and Hematology, First Department of Pediatrics, Medical University of Warsaw, Warsaw, Poland

Publication date: January 1, 2002

More about this publication?
  • The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.

    The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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