Skip to main content
padlock icon - secure page this page is secure

Effects of blue-light-exposure on growth of extracorporeally circulated leukemic cells in rats with leukemia induced by 1-ethyl-1-nitrosourea

Buy Article:

$42.00 + tax (Refund Policy)

To explore the possibility of using blue light for extracorporeal circulation therapy in patients with leukemia, the effects of blue light on cell growth in vitro and in extracorporeally circulated blood of rats with leukemia were evaluated. When HL60 cells circulated extracorporeally using a peristaltic pump were exposed to blue light for 5 h, the growth of the cells was found to be markedly suppressed. Then, the blood of rats with erythroblastic leukemia, induced by the administration of tap water containing l-ethyl-l-nitrosourea (ENU) for 9-16 weeks, was circulated extracorporeally and exposed to blue light for 3 h. Lymphocytes were separated from the peripheral blood immediately after the end of blue-light-exposure and incubated for 7 days. The growth of leukemic cells was found to be significantly suppressed following exposure to blue light, whereas the growth of normal lymphocytes was unaffected. These findings suggest that cancer cells may be more sensitive to blue light than normal cells.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Document Type: Research Article

Affiliations: Otsuka Pharmaceutical Factory, Inc., Muya-cho, Naruto, Tokushima 772-8601, Japan., Email: [email protected]

Publication date: January 1, 2002

More about this publication?
  • The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.

    The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
  • Editorial Board
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Information for Advertisers
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more