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RNA-mediated gene regulation system: Now and the future (Review)

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The discovery of RNA-mediated gene regulation system has brought human beings another big surprise on the wisdom and power of nature. Nature can not only create genetic codes with 4 nucleotides and produce proteins with 21 amino acids, but also control their intermediates, mRNAs, with double-stranded RNA molecules composed of ≈22 nt. It has been clear that ≈22 nt dsRNAs can specifically and efficiently modulate gene expression through sequence-specific targeting thus silencing of RNA. This system promises to be an excellent model for the identification of gene functions and the exploitation of gene expression and phenotype alteration, and a promising way for the prevention and treatment of human diseases.
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Document Type: Research Article

Affiliations: Division of Health Science and Technology, Thorn Building, Boston, MA 02115, USA., Email: [email protected]

Publication date: January 1, 2002

More about this publication?
  • The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.

    The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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