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The effectors of killer activity induced by interferon-α and γ in peripheral blood mononuclear cells

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The nature of effectors of interferon (IFN)-α or IFN-γ-induced killer cell activity remains unclear. The aim of this study was to examine killer cell activity induced by IFN-α alone, IFN-γ alone or a combination of both in patients with renal cell carcinoma (RCC) and to determine the phenotypic patterns of these effectors. The study group included 14 patients (12 men and 2 women, median age 64 years, range 36-77) with confirmed RCC. Peripheral blood mononuclear cells (PBMC) from RCC patients or normal volunteers were cultured with IFN-α alone, IFN-γ alone or a combination of both. Cytotoxic activity was assayed against ACHN cells. Subpopulations of effector cells in IFN-induced killer cell activity were characterized by cell sorting. The most effective type of IFN and the optimal concentration of IFN necessary to induce the maximal killer cell activity varied among RCC patients. The killer activity induced by a combination of IFN-α and IFN-γ was significantly greater than that induced by IFN-α or IFN-γ alone. The greatly increased killer activity induced by IFN-α and IFN-γ was seen in the subpopulations CD3(-) CD16(+), CD3(-) CD56(+) and subpopulation CD3(+)CD4(-), CD3(-)CD16(+), CD3(-)CD56(+), CD57(+)CD16(-), respectively. An optimal type of IFN and optimal concentration of IFN seem to increase the effective rate of treatment of RCC. In addition, the role of IFN-α seems to be different from that of IFN-γ in host defense against RCC. A combination treatment with IFN-α and IFN-γ seems to be suitable to increase the effective rate if we could reduce the side effects of IFNs.
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Document Type: Research Article

Affiliations: Department of Urology, Nagasaki University School of Medicine, Nagasaki, Japan

Publication date: January 1, 2002

More about this publication?
  • The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.

    The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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