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Frequent polymorphism of peroxisome proliferator activated receptor γ gene in colorectal cancer containing wild-type K-ras gene

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We analyzed the K-ras gene mutation and the polymorphism of peroxisome proliferator activated receptor γ (PPARγ) gene, which is known as a master gene for adipocyte differentiation and a tumor suppressor gene, in patients with colorectal cancer by polymerase chain reaction-restriction fragment length polymorphism. We detected a mutation of K-ras gene at codon 12 in 8 of 39 colorectal cancers. We also detected a polymorphism of PPARγ gene at codon 12 in 10 of 39 patients with colorectal cancer. Homozygous polymorphism (Ala12Ala) in PPARγ gene was found only in one patient, but heterozygous polymorphism (Pro12Ala) was found in 9 of 29 patients. Surprisingly, all 10 colorectal cancers developed in the patients with polymorphism of PPARγ gene carrying the wild-type K-ras gene. These findings suggest that PPARγ gene polymorphism may be implicated with the development of colorectal cancers, in which K-ras gene is not mutated.
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Document Type: Research Article

Affiliations: Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Mibu, Shimo-tsuga, Tochigi 321-0293, Japan., Email: [email protected]

Publication date: January 1, 2002

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  • The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.

    The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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