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Home / International Journal of Molecular Medicine, Volume 9, Number 2

Identification of genes coding enzymes for ascomycin tetra-hydropyranose ring formation

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Authors: Uchida, Takafumi; Fujimori, Fumihiro; Nagata, Naoki

Source: International Journal of Molecular Medicine, Volume 9, Number 2, 2002, pp. 141-145(5)

Publisher: Spandidos Publications

Macrocyclic polyketides have generated great interest in biosynthetic chemistry because of the structural complexity and medicinal activities. The synthetic genes consist of the number and type of active sites of modular polyketide synthases. The cosmid library - prepared with the ascomycin (an antibiotics with immunosuppressive activity) - producer, Streptomyces sp. AA6554 genome was screened with an ascomycin ketosynthase gene probe, and one and a half modules were isolated. Database analysis shows that one of the modules consists of the genes coding a series of enzymes for the tetra-hydropyranose ring synthesis.

Document Type: Research Article

Affiliations: Department of Pathology, Institute of Aging, Development and Cancer, Tohoku University, Aoba, Sendai 980-8575, Japan

Publication date: 01 January 2002

More about this publication?
  • The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.

    The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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