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Activation of FcεRI-positive eosinophils in bullous pemphigoid

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Bullous pemphigoid (BP) is an autoimmune disease frequently occurring in elderly persons. It has been reported that 92-kDa gelatinase released from eosinophils cleaves the extracellular domain of BP180 protein, suggesting a direct role of eosinophils in bulla formation in this disease. The expression of the high-affinity IgE receptor, FcεRI, on eosinophils was examined in patient with BP. Samples of affected skin obtained from 7 patients with BP were stained immunohistochemically by the alkaline phosphatase anti-alkaline phosphatase (APAAP) method and mirror sections were examined. Eosinophils were present at a rate of 1.0-19.0% in lesions of the dermis, and the number of IgE-positive cells exceeded that of FcεRI-positive cells in all cases. These cells were not detected in the epidermis, and examination of mirror sections confirmed that the FcεRI-positive cells corresponded to eosinophils. It has been demonstrated that FcεRI-positive cells are involved in the dermal lesions of BP. The activation of eosinophils by FcεRI may participate in the pathogenesis of BP by triggering the degranulation of mast cells.
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Document Type: Research Article

Affiliations: Department of Dermatology, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan

Publication date: March 1, 2001

More about this publication?
  • The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.

    The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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