@article {Okamoto:2001:1107-3756:177,
title = "Inhibition of anti-Fas antibody-induced mice hepatitis by furocoumarin derivatives",
journal = "International Journal of Molecular Medicine",
parent_itemid = "infobike://sp/ijmm",
publishercode ="sp",
year = "2001",
volume = "7",
number = "2",
publication date ="2001-01-01T00:00:00",
pages = "177-180",
itemtype = "ARTICLE",
issn = "1107-3756",
eissn = "1791-244X",
url = "https://www.ingentaconnect.com/content/sp/ijmm/2001/00000007/00000002/art00009",
author = "Okamoto and Yoshida and Kobayashi and Okabe",
abstract = "The effects of imperatorin and its synthetic derivative, Y355, on anti-Fas antibody-induced mice hepatitis were studied. Pretreatment of mice by intraperitoneal administration of imperatorine or Y355 at 30 mg/kg inhibited more than 80% of the anti-Fas antibody (150 g/kg, i.v.)-induced
elevation of plasma alanine aminotransferase activity. Furthermore, oral administration of imperatorin or Y355 at 100 mg/kg also had an inhibitory effect on anti-Fas antibody-induced hepatitis. Both compounds inhibited anti-Fas antibody (250 g/kg)-induced caspase-1 and caspase-3 activities.
The present results showed the inhibition of anti-Fas antibody-induced hepatitis by imperatorin and Y355, which might be a result of inhibition of caspase activities.",
}