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Divergent effects of paracetamol on reactive oxygen intermediate and reactive nitrogen intermediate production by U937 cells.

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We investigated the effects of paracetamol on reactive oxygen intermediate and reactive nitrogen intermediate production by U937 cells. Cells which had been treated with paracetamol (0.01 microM - 10 microM) exhibited a significant (p<0.001) increase in hydrogen peroxide production and a significant (p<0.001) increase in phorbol 12-myristate 13-acetate induced superoxide production. Conversely, paracetamol (0.01 microM - 10 microM) caused a significant (p<0.001) decrease in the amount of nitrite secreted into the culture medium. Our results indicate divergent effects of paracetamol on ROI and RNI production.
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Document Type: Research Article

Affiliations: Division of Biomedical Sciences, School of Health Sciences, University of Wolverhampton, Wolverhampton WV1 1DJ, UK.

Publication date: September 1, 1999

More about this publication?
  • The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.

    The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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