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In vitro interaction of serum protein with circulating DNA of lung cancer patient.

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Circulating DNA and oncoproteins can be extracted from serum or plasma of cancer patients. In this study, using gel retardation analysis we observed circulating DNA obtained from plasma of a lung cancer patient complexed with serum proteins. p53 was identified by immunoblotting as one of the proteins present in the complex. Our finding suggests that the same interaction observed between p53 and DNA in intact cells occurs in serum of lung cancer patient. As far as we know this is the first evidence for such finding.
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Document Type: Research Article

Affiliations: Laboratório de Controle da Expressão Genica, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Ilha do Fundão, RJ, Brazil.

Publication date: August 1, 1999

More about this publication?
  • The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.

    The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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