Potassium-current oscillation of rat megakaryocytes: As a model system for drug evaluation (Review).
Megakaryocytes respond to externally applied agonists showing a periodic K+ current that reflects oscillation in cytoplasmic calcium concentration ([Ca2+]i). We have revealed several signal transducing factors that are involved in the K+ current oscillation of megakaryocytes. In this megakaryocyte system, it is relatively easy to determine what point of the signal transduction pathway a drug affects. In addition, as a progenitor cell, megakaryocytes resemble platelets which have important roles in many diseases. Therefore, this experimental system can be used for evaluation of new drugs.
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Document Type: Research Article
Affiliations: Division of Pathology, National Institute of Health Sciences, Setagaya-ku 158-8501, Japan.
Publication date: August 1, 1999
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- The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.
The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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