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Control of vascular smooth muscle cell growth and its implication in atherosclerosis and restenosis (review).

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Abnormal proliferation of vascular smooth muscle cells (SMCs) is thought to contribute to neointimal thickening during spontaneous atherosclerosis and vessel renarrowing (restenosis) after angioplasty. This review will focus on the mechanisms underlying cell-cycle control in SMCs and its implication in atherosclerosis and restenosis. Therapeutic approaches that targeted specific cell-cycle control genes or growth regulatory molecules which effectively inhibited neointimal lesion formation will also be discussed.
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Document Type: Research Article

Affiliations: Division of Cardiovascular Research, St. Elizabeth's Medical Center, Boston, MA 02135, USA.

Publication date: January 1, 1998

More about this publication?
  • The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.

    The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases.
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