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Interleukin1A and interleukin1B gene polymorphisms in gastroesophageal reflux disease

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Inflammation may play contradictory roles in the pathogenesis of gastroesophageal reflux diseaseĀ (GERD): gastritis decreases gastric output and reduces the risk of esophagitis, while interleukins may favor mucosal inflammation. The inflammation may cause esogastric motility changes and thus increase the risk of esophagitis. Considering the genetic influence of inflammatory response, we looked for the genetic polymorphisms of IL1 in GERD manifested as reflux esophagitis. This is a prospective study carried out in GERD and healthy controls. We assessed in these groups the following single nucleotide polymorphisms (SNPs): IL1A (rs1800587), IL1B (rs16944), IL1B (rs1143634) and the VNTR for IL1RN. Both groups were similar according to biographical data. Reflux esophagitis was confirmed by endoscopy and where necessary by pHimpedance monitoring. Reflux esophagitis was associated only with the polymorphism rs16944. No other correlations with the other three genetic polymorphisms were detected. These data suggest that the diverging effects of proinflammatory factors on the upper digestive tract may have deleterious effect on GERD. The IL1B (rs16944) SNP correlates with reflux esophagitis.
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Document Type: Research Article

Affiliations: 1: Faculty of Dental Medicine, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, 400006 ClujNapoca, Romania 2: Department of Molecular Sciences, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, 400012 ClujNapoca, Romania 3: Faculty of Mathematics and Informatics, ‘BabesBolyai’ University, 400084 ClujNapoca, Romania 4: 2nd Department of Internal Medicine, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, 400003 ClujNapoca, Romania

Publication date: October 1, 2020

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  • Experimental and Therapeutic Medicine aims to ensure the expedient publication, in both print and electronic format, of studies relating to biology, gene therapy, infectious disease, microbiology, molecular cardiology and molecular surgery. The journal welcomes studies pertaining to all aspects of molecular medicine, and studies relating to in vitro or in vivo experimental model systems relevant to the mechanisms of disease are also included.

    All materials submitted to this journal undergo the appropriate review via referees who are experts in this field. All materials submitted follow international guidelines with regard to approval of experiments on humans and animals.
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