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Establishment of a rat model with ageing insomnia induced by Dgalactosef and parachlorophenylalanine

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The current study aimed to establish a rat model of ageing insomnia induced by Dgalactose and/or parachlorophenylalanine. Following establishment of the model, body weights were measured, and Morris water maze and pentobarbitalinduced sleep tests were performed. The serum levels of inflammatory mediators and the neural levels of neurotransmitters were detected. The results demonstrated that the body weights of PCPA+Dgalinduced ageing insomnia rats decreased significantly. Ageing insomnia rats exhibited longer latencies to the platform in the Morris water maze tests and fewer target crossings. The sleep latency of the model rats was longer and sleep time was shorter by contrast. The relative expression of hippocampal IL6, TNFα, NFκB and mGluR2 mRNA of the PCPA+Dgalinduced ageing insomnia group was higher, while the relative expression of 5HT1AR and GABAARa1 mRNA were lower. The serum levels of IL1β, IL6, TNFα and brain level of glutamate increased in the PCPA+Dgalinduced ageing insomnia group, while the levels of 5HT and GABA decreased. In conclusion, memory function, sleep time, expression of inflammatory factors and neurotransmitters are altered in ageing insomnia rats induced by Dgalactose and parachlorophenylalanine, indicating the successful establishment of a murine model of ageing insomnia.
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Document Type: Research Article

Affiliations: 1: Department of Internal Medicine, Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University, Urumqi, Xinjiang 830000, P.R. China 2: Department of Gerontology, Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University, Urumqi, Xinjiang 830000, P.R. China 3: College of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China

Publication date: October 1, 2020

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  • Experimental and Therapeutic Medicine aims to ensure the expedient publication, in both print and electronic format, of studies relating to biology, gene therapy, infectious disease, microbiology, molecular cardiology and molecular surgery. The journal welcomes studies pertaining to all aspects of molecular medicine, and studies relating to in vitro or in vivo experimental model systems relevant to the mechanisms of disease are also included.

    All materials submitted to this journal undergo the appropriate review via referees who are experts in this field. All materials submitted follow international guidelines with regard to approval of experiments on humans and animals.
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