A nomogram for the prediction of renal outcomes among patients with idiopathic membranous nephropathy

The early prediction of renal outcomes in patients with idiopathic membranous nephropathy (iMN) remains challenging. The present retrospective study evaluated patients with iMN confirmed by renal biopsy. An optimized Cox regression model and a nomogram were constructed for the early prediction of renal outcomes. A total of 141 patients who met the inclusion criteria were evaluated in the present study. In total 18 (12.8%) patients eventually progressed to the endpoint, 6 of whom developed endstage renal disease, and one patient died during followup. The optimized model demonstrated that 24h proteinuria [hazard ratio (HR) 1.24; 95% CI, 1.101.40; Pvalue <0.001] and chronic tubulointerstitial injury [referred to as grade 0, grade 1 (HR), 5.12; 95% CI, 1.3319.75; Pvalue=0.02] or grade 2 (HR, 6.43; 95% CI, 1.3530.59; Pvalue=0.02) were independent risk factors for a poor renal outcome. Patients with an estimated threeyear renal survival rate (ETR) less than 0.87 had a high risk of a poor renal outcome. In addition, patients with an ETR of 0.87 to 0.98 more quickly developed a decreased estimated glomerular filtration rate after two years of followup. In the present study a nomogram for the early prediction of renal outcomes in patients with iMN was developed. This nonogram suggested that patients with an ETR of 0.870.98 should receive greater attention during followup.